Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs

The Hippo signaling pathway acts as a brake on regeneration in many tissues. This cascade of kinases culminates in the phosphorylation of the transcriptional cofactors Yap and Taz, whose concentration in the nucleus consequently remains low. Various types of cellular signals can reduce phosphorylati...

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Detalles Bibliográficos
Autores principales: Kastan, Nathaniel R., Oak, Sanyukta, Liang, Rui, Baxt, Leigh, Myers, Robert W., Ginn, John, Liverton, Nigel, Huggins, David J., Pichardo, John, Paul, Matthew, Carroll, Thomas S., Nagiel, Aaron, Gnedeva, Ksenia, Hudspeth, A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282237/
https://www.ncbi.nlm.nih.gov/pubmed/35867764
http://dx.doi.org/10.1073/pnas.2206113119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282237/
https://www.ncbi.nlm.nih.gov/pubmed/35867764
http://dx.doi.org/10.1073/pnas.2206113119

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