Genetic and structural basis of the human anti-α-galactosyl antibody response

Humans lack the capacity to produce the Galα1–3Galβ1–4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut bacteria, malaria parasites, cetuximab, and tick proteins. Here we use X-ray crystallographic analy...

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Detalles Bibliográficos
Autores principales: Langley, David B., Schofield, Peter, Nevoltris, Damien, Jackson, Jennifer, Jackson, Katherine J. L., Peters, Tim J., Burk, Melanie, Matthews, Jacqueline M., Basten, Antony, Goodnow, Christopher C., van Nunen, Sheryl, Reed, Joanne H., Christ, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282431/
https://www.ncbi.nlm.nih.gov/pubmed/35867757
http://dx.doi.org/10.1073/pnas.2123212119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282431/
https://www.ncbi.nlm.nih.gov/pubmed/35867757
http://dx.doi.org/10.1073/pnas.2123212119

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