OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood. Here, we characterize a family with myopathy caused by a dominant p.G58R mutation in the mitochondrial protein CHCHD10. To understand the dise...

Descripción completa

Detalles Bibliográficos
Autores principales: Shammas, Mario K., Huang, Xiaoping, Wu, Beverly P., Fessler, Evelyn, Song, Insung Y., Randolph, Nicholas P., Li, Yan, Bleck, Christopher K.E., Springer, Danielle A., Fratter, Carl, Barbosa, Ines A., Powers, Andrew F., Quirós, Pedro M., Lopez-Otin, Carlos, Jae, Lucas T., Poulton, Joanna, Narendra, Derek P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282932/
https://www.ncbi.nlm.nih.gov/pubmed/35700042
http://dx.doi.org/10.1172/JCI157504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282932/
https://www.ncbi.nlm.nih.gov/pubmed/35700042
http://dx.doi.org/10.1172/JCI157504

Ejemplares similares