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OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy
Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood. Here, we characterize a family with myopathy caused by a dominant p.G58R mutation in the mitochondrial protein CHCHD10. To understand the dise...
Autores principales: | Shammas, Mario K., Huang, Xiaoping, Wu, Beverly P., Fessler, Evelyn, Song, Insung Y., Randolph, Nicholas P., Li, Yan, Bleck, Christopher K.E., Springer, Danielle A., Fratter, Carl, Barbosa, Ines A., Powers, Andrew F., Quirós, Pedro M., Lopez-Otin, Carlos, Jae, Lucas T., Poulton, Joanna, Narendra, Derek P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282932/ https://www.ncbi.nlm.nih.gov/pubmed/35700042 http://dx.doi.org/10.1172/JCI157504 |
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