Amyloid beta induces Fmr1‐dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2

Alzheimer's disease (AD) is the most common cause of dementia, with the accumulation of amyloid beta peptide (Aβ) being one of the main causes of the disease. Fragile X mental retardation protein (FMRP), encoded by fragile X mental retardation 1 (Fmr1), is an RNA‐binding protein that represses...

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Detalles Bibliográficos
Autores principales: Lizarazo, Simon, Yook, Yeeun, Tsai, Nien‐Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283232/
https://www.ncbi.nlm.nih.gov/pubmed/35434801
http://dx.doi.org/10.1002/jcp.30754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283232/
https://www.ncbi.nlm.nih.gov/pubmed/35434801
http://dx.doi.org/10.1002/jcp.30754

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