Potentiating adoptive cell therapy using synthetic IL-9 receptors

Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of solid tumours, including the need for conditioning chemotherapy(1,2). Here we designed chimeric receptors that have an orthogonal IL-2 receptor...

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Detalles Bibliográficos
Autores principales: Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J., Ribas, Antoni, June, Carl H., Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283313/
https://www.ncbi.nlm.nih.gov/pubmed/35676488
http://dx.doi.org/10.1038/s41586-022-04801-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283313/
https://www.ncbi.nlm.nih.gov/pubmed/35676488
http://dx.doi.org/10.1038/s41586-022-04801-2

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