ATP-Activated P2X7R Promote the Attack of Acute Gouty Arthritis in Rats Through Activating NLRP3 Inflammasome and Inflammatory Cytokine Production

OBJECTIVE: To investigate the effect of P2X7R on MSU crystal-induced acute gouty arthritis in rats and its mechanism on inflammatory responses. METHODS: In vivo activation or inhibition of P2X7R was examined in the ATP group or the BBG group of rats, and the control group were injected with PBS. All...

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Detalles Bibliográficos
Autores principales: Dai, Xiaojuan, Fang, Xuan, Xia, Yuan, Li, Manyun, Li, Xiaomei, Wang, Yiping, Tao, Jinhui, Li, Xiangpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283387/
https://www.ncbi.nlm.nih.gov/pubmed/35845088
http://dx.doi.org/10.2147/JIR.S351660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283387/
https://www.ncbi.nlm.nih.gov/pubmed/35845088
http://dx.doi.org/10.2147/JIR.S351660

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