Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase

When overexpressed as an immature enzyme in the mesophilic bacterium Escherichia coli, recombinant homoserine dehydrogenase from the hyperthermophilic archaeon Sulfurisphaera tokodaii (StHSD) was markedly activated by heat treatment. Both the apo- and holo-forms of the immature enzyme were successiv...

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Detalles Bibliográficos
Autores principales: Kubota, Tatsuya, Kurihara, Erika, Watanabe, Kazuya, Ogata, Kohei, Kaneko, Ryosuke, Goto, Masaru, Ohshima, Toshihisa, Yoshimune, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283420/
https://www.ncbi.nlm.nih.gov/pubmed/35835834
http://dx.doi.org/10.1038/s42003-022-03656-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283420/
https://www.ncbi.nlm.nih.gov/pubmed/35835834
http://dx.doi.org/10.1038/s42003-022-03656-7

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