Engineered sTRAIL-armed MSCs overcome STING deficiency to enhance the therapeutic efficacy of radiotherapy for immune checkpoint blockade

Radiotherapy (RT) mainly elicits antitumor immunity via the cGAS/STING axis for type I interferon (IFN) production. However, dysregulation of cGAS/STING constrains radiotherapy-induced antitumor immunity and type I IFN-dependent cell death and is associated with shorter survival of patients with col...

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Detalles Bibliográficos
Autores principales: Huang, Kevin Chih-Yang, Chiang, Shu-Fen, Chang, Hsin-Yu, Chen, William Tzu-Liang, Yang, Pei-Chen, Chen, Tsung-Wei, Liang, Ji-An, Shiau, An‑Cheng, Ke, Tao-Wei, Clifford Chao, K. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283452/
https://www.ncbi.nlm.nih.gov/pubmed/35835756
http://dx.doi.org/10.1038/s41419-022-05069-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283452/
https://www.ncbi.nlm.nih.gov/pubmed/35835756
http://dx.doi.org/10.1038/s41419-022-05069-0

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