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β-Adrenergic Receptor Desensitization/Down-Regulation in Heart Failure: A Friend or Foe?
Cardiac sympathetic activation, mediated by β-adrenergic receptors (β-ARs), normally increases cardiac contraction and relaxation. Accomplishing this task requires a physiological, concerted Ca(2+) signaling, being able to increase Ca(2+) release from sarcoplasmic reticulum (SR) in systole and speed...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283919/ https://www.ncbi.nlm.nih.gov/pubmed/35845057 http://dx.doi.org/10.3389/fcvm.2022.925692 |