An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver

It is widely accepted that activating the transcription factor NRF2 will blast the physiological anti-inflammatory mechanisms, which will help combat pathologic inflammation. Much effort is being put in inhibiting the main NRF2 repressor, KEAP1, with either electrophilic small molecules or disrupter...

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Detalles Bibliográficos
Autores principales: Fernández-Ginés, Raquel, Encinar, José Antonio, Hayes, John D., Oliva, Baldo, Rodríguez-Franco, Maria Isabel, Rojo, Ana I., Cuadrado, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283934/
https://www.ncbi.nlm.nih.gov/pubmed/35839629
http://dx.doi.org/10.1016/j.redox.2022.102396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283934/
https://www.ncbi.nlm.nih.gov/pubmed/35839629
http://dx.doi.org/10.1016/j.redox.2022.102396

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