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Irradiation combined with PD-L1(−/−) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation
Radiotherapy combined with immune checkpoint blockade has gradually revealed the superiority in the antitumor therapy; however, the contribution of host PD-L1 remains elusive. In this study, we found that the activation of CD8(+) T cells was strikingly increased in both irradiated PD-L1-expressing p...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283938/ https://www.ncbi.nlm.nih.gov/pubmed/35847556 http://dx.doi.org/10.1016/j.isci.2022.104690 |