Irradiation combined with PD-L1(−/−) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation

Radiotherapy combined with immune checkpoint blockade has gradually revealed the superiority in the antitumor therapy; however, the contribution of host PD-L1 remains elusive. In this study, we found that the activation of CD8(+) T cells was strikingly increased in both irradiated PD-L1-expressing p...

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Detalles Bibliográficos
Autores principales: Zhao, Xinrui, Hu, Songling, Zeng, Liang, Liu, Xinglong, Song, Yimeng, Zhang, Yuhong, Chen, Qianping, Bai, Yang, Zhang, Jianghong, Zhang, Haowen, Pan, Yan, Shao, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283938/
https://www.ncbi.nlm.nih.gov/pubmed/35847556
http://dx.doi.org/10.1016/j.isci.2022.104690

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