Self-activating G protein α subunits engage seven-transmembrane regulator of G protein signaling (RGS) proteins and a Rho guanine nucleotide exchange factor effector in the amoeba Naegleria fowleri

The free-living amoeba Naegleria fowleri is a causative agent of primary amoebic meningoencephalitis and is highly resistant to current therapies, resulting in mortality rates >97%. As many therapeutics target G protein–centered signal transduction pathways, further understanding the functional s...

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Detalles Bibliográficos
Autores principales: Bosch, Dustin E., Jeck, William R., Siderovski, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283941/
https://www.ncbi.nlm.nih.gov/pubmed/35738399
http://dx.doi.org/10.1016/j.jbc.2022.102167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283941/
https://www.ncbi.nlm.nih.gov/pubmed/35738399
http://dx.doi.org/10.1016/j.jbc.2022.102167

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