Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation

Dysfunctional triglyceride‐very low‐density lipoprotein (TG‐VLDL) metabolism is linked to metabolic‐associated fatty liver disease (MAFLD); however, the underlying cause remains unclear. The study shows that hepatic E3 ubiquitin ligase murine double minute 2 (MDM2) controls MAFLD by blocking TG‐VLDL...

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Detalles Bibliográficos
Autores principales: Lin, Huige, Wang, Lin, Liu, Zhuohao, Long, Kekao, Kong, Mengjie, Ye, Dewei, Chen, Xi, Wang, Kai, Wu, Kelvin KL, Fan, Mengqi, Song, Erfei, Wang, Cunchuan, Hoo, Ruby LC, Hui, Xiaoyan, Hallenborg, Philip, Piao, Hailong, Xu, Aimin, Cheng, Kenneth KY
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284139/
https://www.ncbi.nlm.nih.gov/pubmed/35524581
http://dx.doi.org/10.1002/advs.202200742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284139/
https://www.ncbi.nlm.nih.gov/pubmed/35524581
http://dx.doi.org/10.1002/advs.202200742

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