JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport

The MAP kinase and motor scaffold JIP3 prevents excess lysosome accumulation in axons of vertebrates and invertebrates. How JIP3’s interaction with dynein and kinesin-1 contributes to organelle clearance is unclear. We show that human dynein light intermediate chain (DLIC) binds the N-terminal RH1 d...

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Detalles Bibliográficos
Autores principales: Celestino, Ricardo, Gama, José B., Castro-Rodrigues, Artur F., Barbosa, Daniel J., Rocha, Helder, d’Amico, Ennio A., Musacchio, Andrea, Carvalho, Ana Xavier, Morais-Cabral, João H., Gassmann, Reto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284427/
https://www.ncbi.nlm.nih.gov/pubmed/35829703
http://dx.doi.org/10.1083/jcb.202110057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284427/
https://www.ncbi.nlm.nih.gov/pubmed/35829703
http://dx.doi.org/10.1083/jcb.202110057

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