Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma

Expression of the fusion oncoprotein EWS/FLI causes Ewing sarcoma, an aggressive pediatric tumor characterized by widespread epigenetic deregulation. These epigenetic changes are targeted by novel lysine-specific demethylase-1 (LSD1) inhibitors, which are currently in early-phase clinical trials. Si...

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Detalles Bibliográficos
Autores principales: Tokarsky, E. John, Crow, Jesse C., Guenther, Lillian M., Sherman, John, Taslim, Cenny, Alexe, Gabriela, Pishas, Kathleen I., Rask, Galen, Justis, Blake S., Kasumova, Ana, Stegmaier, Kimberly, Lessnick, Stephen L., Theisen, Emily R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Cancer Genes and Networks
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284474/
https://www.ncbi.nlm.nih.gov/pubmed/35298000
http://dx.doi.org/10.1158/1541-7786.MCR-22-0027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284474/
https://www.ncbi.nlm.nih.gov/pubmed/35298000
http://dx.doi.org/10.1158/1541-7786.MCR-22-0027

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