Highly sensitive quantification of pemetrexed in human plasma using UPLC‐MS/MS to support microdosing studies

Pemetrexed is an antifolate drug approved for the treatment of non‐small‐cell lung cancer and mesothelioma. Assessing pemetrexed pharmacokinetics after administration of a microdose (100 μg) may facilitate drug–drug interaction and dose individualization studies with cytotoxic drugs, without causing...

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Detalles Bibliográficos
Autores principales: van Ewijk‐Beneken Kolmer, Eleonora W. J., Teulen, Marga J. A., Boosman, Rene J., de Rouw, Nikki, Burgers, Jacobus A., ter Heine, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285051/
https://www.ncbi.nlm.nih.gov/pubmed/34741344
http://dx.doi.org/10.1002/bmc.5277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285051/
https://www.ncbi.nlm.nih.gov/pubmed/34741344
http://dx.doi.org/10.1002/bmc.5277

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