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Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV‐1 vaginal microbicides

Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy, most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 (HIV‐1) in human clinical trials. In vitro, ex vivo, and in vivo models must be optimized, considering the knowle...

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Detalles Bibliográficos
Autores principales: Rodríguez‐Izquierdo, Ignacio, Sepúlveda‐Crespo, Daniel, Lasso, Jose María, Resino, Salvador, Muñoz‐Fernández, Ma Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285063/
https://www.ncbi.nlm.nih.gov/pubmed/35018739
http://dx.doi.org/10.1002/wnan.1774