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Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer

Gasdermins (GSDMs) are a class of pore-forming proteins related to pyroptosis, a programmed cell death pathway that is induced by a range of inflammatory stimuli. Small-scale GSDM activation and pore formation allow the passive release of cytokines, such as IL-1β and IL-18, and alarmins, but, whenev...

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Detalles Bibliográficos
Autores principales: Magnani, Laura, Colantuoni, Mariasilvia, Mortellaro, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285118/
https://www.ncbi.nlm.nih.gov/pubmed/35844522
http://dx.doi.org/10.3389/fimmu.2022.898298