Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation‐induced deficits in spatial pattern separation

Sleep deprivation (SD) is known to impair hippocampus‐dependent memory processes, in part by stimulating the phosphodiesterase (PDE) activity. In the present study, we assessed in mice whether SD also affects spatial pattern separation, a cognitive process that specifically requires the dentate gyru...

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Detalles Bibliográficos
Autores principales: Heckman, Pim R. A., Roig Kuhn, Femke, Raven, Frank, Bolsius, Youri G., Prickaerts, Jos, Meerlo, Peter, Havekes, Robbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285343/
https://www.ncbi.nlm.nih.gov/pubmed/32056276
http://dx.doi.org/10.1002/syn.22150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285343/
https://www.ncbi.nlm.nih.gov/pubmed/32056276
http://dx.doi.org/10.1002/syn.22150

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