Structure of prion β‐oligomers as determined by short‐distance crosslinking constraint‐guided discrete molecular dynamics simulations

The conversion of the native monomeric cellular prion protein (PrP(C)) into an aggregated pathological β‐oligomeric form (PrP(β)) and an infectious form (PrP(Sc)) is the central element in the development of prion diseases. The structure of the aggregates and the molecular mechanisms of the conforma...

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Detalles Bibliográficos
Autores principales: Serpa, Jason J., Popov, Konstantin I., Petrotchenko, Evgeniy V., Dokholyan, Nikolay V., Borchers, Christoph H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285417/
https://www.ncbi.nlm.nih.gov/pubmed/34482645
http://dx.doi.org/10.1002/pmic.202000298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285417/
https://www.ncbi.nlm.nih.gov/pubmed/34482645
http://dx.doi.org/10.1002/pmic.202000298

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