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Structure of prion β‐oligomers as determined by short‐distance crosslinking constraint‐guided discrete molecular dynamics simulations
The conversion of the native monomeric cellular prion protein (PrP(C)) into an aggregated pathological β‐oligomeric form (PrP(β)) and an infectious form (PrP(Sc)) is the central element in the development of prion diseases. The structure of the aggregates and the molecular mechanisms of the conforma...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285417/ https://www.ncbi.nlm.nih.gov/pubmed/34482645 http://dx.doi.org/10.1002/pmic.202000298 |