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Flavan‐3‐ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid‐beta (1‐42) Levels

INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegeneration characterized by extensive protein aggregation and deposition in the brain, associated with defective proteasomal and autophagic‐lysosomal proteolytic pathways. Since current drugs can only reduce specific symptoms, the i...

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Detalles Bibliográficos
Autores principales: Cecarini, Valentina, Cuccioloni, Massimiliano, Zheng, Yadong, Bonfili, Laura, Gong, Chunmei, Angeletti, Mauro, Mena, Pedro, Del Rio, Daniele, Eleuteri, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285603/
https://www.ncbi.nlm.nih.gov/pubmed/34318994
http://dx.doi.org/10.1002/mnfr.202100380