Bioactivity improvement via display of the hydrophobic core of HYD1 in a cyclic β‐hairpin‐like scaffold, MTI‐101

HYD1 is an all D‐amino acid linear 10‐mer peptide that was discovered by one‐bead‐one‐compound screening. HYD1 has five hydrophobic amino acids flanked by polar amino acids. Alanine scanning studies showed that alternating hydrophobic amino acid residues and N‐ and C‐terminal lysine side chains were...

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Detalles Bibliográficos
Autores principales: Jain, Priyesh, Badger, David B., Liang, Yi, Gebhard, Anthony W., Santiago, Daniel, Murray, Philip, Kaulagari, Sridhar R., Gauthier, Ted J., Nair, Rajesh, Kumar, MohanRaja, Guida, Wayne C., Hazlehurst, Lori A., McLaughlin, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285608/
https://www.ncbi.nlm.nih.gov/pubmed/35859761
http://dx.doi.org/10.1002/pep2.24199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285608/
https://www.ncbi.nlm.nih.gov/pubmed/35859761
http://dx.doi.org/10.1002/pep2.24199

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