Synthesis and Screening of a DNA‐Encoded Library of Non‐Peptidic Macrocycles

There is considerable interest in the development of libraries of non‐peptidic macrocycles as a source of ligands for difficult targets. We report here the solid‐phase synthesis of a DNA‐encoded library of several hundred thousand thioether‐linked macrocycles. The library was designed to be highly d...

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Detalles Bibliográficos
Autores principales: Koesema, Eric, Roy, Animesh, Paciaroni, Nicholas G., Coito, Carlos, Tokmina‐Roszyk, Michal, Kodadek, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285660/
https://www.ncbi.nlm.nih.gov/pubmed/35192245
http://dx.doi.org/10.1002/anie.202116999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285660/
https://www.ncbi.nlm.nih.gov/pubmed/35192245
http://dx.doi.org/10.1002/anie.202116999

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