Backbone distortions in lactam‐bridged helical peptides

Side‐chain‐to‐side‐chain cyclization is frequently used to stabilize the α‐helical conformation of short peptides. In a previous study, we incorporated a lactam bridge between the side chains of Lys‐i and Asp‐i+4 in the nonapeptide 1Y, cyclo‐(2,6)‐(Ac‐VKRLQDLQY‐NH ( 2 )), an artificial ligand of the...

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Detalles Bibliográficos
Autores principales: Moazzam, Ali, Stanojlovic, Vesna, Hinterholzer, Arthur, Holzner, Christoph, Roschger, Cornelia, Zierer, Andreas, Wiederstein, Markus, Schubert, Mario, Cabrele, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285742/
https://www.ncbi.nlm.nih.gov/pubmed/34984761
http://dx.doi.org/10.1002/psc.3400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285742/
https://www.ncbi.nlm.nih.gov/pubmed/34984761
http://dx.doi.org/10.1002/psc.3400

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