Cargando…

PBK Model‐Based Prediction of Intestinal Microbial and Host Metabolism of Zearalenone and Consequences for its Estrogenicity

SCOPE: The aim of the present study is to develop physiologically‐based kinetic (PBK) models for rat and human that include intestinal microbial and hepatic metabolism of zearalenone (ZEN) in order to predict systemic concentrations of ZEN and to obtain insight in the contribution of metabolism by t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mendez‐Catala, Diana M., Wang, Qianrui, Rietjens, Ivonne M.C.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285883/ https://www.ncbi.nlm.nih.gov/pubmed/34648686 http://dx.doi.org/10.1002/mnfr.202100443

Ejemplares similares

An in vitromodel to quantify interspecies differences in kinetics for intestinal microbial bioactivation and detoxification of zearalenone
por: Mendez-Catala, Diana M., et al.
Publicado: (2020)

Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol
por: Wang, Qianrui, et al.
Publicado: (2021)

Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S‐Equol and Its Consequences for ERα Activation
por: Wang, Qianrui, et al.
Publicado: (2020)

Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry
por: Omwenga, Isaac, et al.
Publicado: (2021)

Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols
por: Strikwold, Marije, et al.
Publicado: (2016)

Zearalenone, an Estrogenic Mycotoxin, Is an Immunotoxic Compound
por: Hueza, Isis M., et al.
Publicado: (2014)

Biotransformation of the Mycotoxin Zearalenone to its Metabolites Hydrolyzed Zearalenone (HZEN) and Decarboxylated Hydrolyzed Zearalenone (DHZEN) Diminishes its Estrogenicity In Vitro and In Vivo
por: Fruhauf, Sebastian, et al.
Publicado: (2019)

Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome(™) cytochromes P450 (CYP)-specific kinetic data as model input
por: Zhao, Shensheng, et al.
Publicado: (2022)

Aflatoxin B1 in nixtamalized maize in Mexico; occurrence and accompanying risk assessment
por: Gilbert Sandoval, Ixchel, et al.
Publicado: (2019)

Interindividual Differences in Human In Vitro Intestinal Microbial Conversion of Green Tea (‐)‐Epigallocatechin‐3‐O‐Gallate and Consequences for Activation of Nrf2 Mediated Gene Expression
por: Liu, Chen, et al.
Publicado: (2020)

Zearalenone toxicosis on reproduction as estrogen receptor selective modulator and alleviation of zearalenone biodegradative agent in pregnant sows
por: Zhou, Jianchuan, et al.
Publicado: (2022)

Effect of Gamma-Radiation on Zearalenone—Degradation, Cytotoxicity and Estrogenicity
por: Calado, Thalita, et al.
Publicado: (2020)

Interindividual Differences in In Vitro Human Intestinal Microbial Conversion of 3-Acetyl-DON and 15-Acetyl-DON
por: Li, Fangfang, et al.
Publicado: (2022)

Effects of Intestinal Microorganisms on Metabolism and Toxicity Mitigation of Zearalenone in Broilers
por: Jia, Sifan, et al.
Publicado: (2022)

Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review
por: Balló, András, et al.
Publicado: (2023)

Next Generation Risk Assessment of the Anti-Androgen Flutamide Including the Contribution of Its Active Metabolite Hydroxyflutamide
por: van Tongeren, Tessa C.A., et al.
Publicado: (2022)

Activity of Zearalenone in the Porcine Intestinal Tract
por: Gajęcka, Magdalena, et al.
Publicado: (2016)

Interindividual Differences in Human Intestinal Microbial Conversion of (−)-Epicatechin to Bioactive Phenolic Compounds
por: Liu, Chen, et al.
Publicado: (2020)

Zearalenone (ZEN) in Livestock and Poultry: Dose, Toxicokinetics, Toxicity and Estrogenicity
por: Liu, Jundi, et al.
Publicado: (2020)

Glucuronidation as a metabolic barrier against zearalenone in rat everted intestine
por: IEKO, Takahiro, et al.
Publicado: (2019)

Intra- and Inter-individual Differences in the Human Intestinal Microbial Conversion of (-)-Epicatechin and Bioactivity of Its Major Colonic Metabolite 5-(3′,4′-Dihydroxy-Phenyl)-γ-Valerolactone in Regulating Nrf2-Mediated Gene Expression
por: Liu, Chen, et al.
Publicado: (2022)

PBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas
por: Zhu, Kejing, et al.
Publicado: (2022)

The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon‐containing extracts of petroleum substances
por: Kamelia, Lenny, et al.
Publicado: (2019)

PBK/TOPK Expression Predicts Prognosis in Oral Cancer
por: Chang, Chin-Fang, et al.
Publicado: (2016)

PBK/TOPK: A Therapeutic Target Worthy of Attention
por: Han, Ziping, et al.
Publicado: (2021)

An Integrative Pan-Cancer Analysis of PBK in Human Tumors
por: Wen, Huantao, et al.
Publicado: (2021)

A Novel Microbial Zearalenone Transformation through Phosphorylation
por: Zhu, Yan, et al.
Publicado: (2021)

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach
por: Abdullah, Rozaini, et al.
Publicado: (2020)

Metabolism of Zearalenone in the Rumen of Dairy Cows with and without Application of a Zearalenone-Degrading Enzyme
por: Gruber-Dorninger, Christiane, et al.
Publicado: (2021)

Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones
por: Grgic, Dino, et al.
Publicado: (2022)

Metabolism of Zearalenone and Its Major Modified Forms in Pigs
por: Binder, Sabina B., et al.
Publicado: (2017)

Metabolism of Zearalenone in the Course of Beer Fermentation
por: Mizutani, Kohei, et al.
Publicado: (2011)

In silico methods for metabolomic and toxicity prediction of zearalenone, α-zearalenone and β-zearalenone
por: Agahi, Fojan, et al.
Publicado: (2020)

Integrating In Vitro Data and Physiologically Based Kinetic Modeling to Predict and Compare Acute Neurotoxic Doses of Saxitoxin in Rats, Mice, and Humans
por: Chen, Jiaqi, et al.
Publicado: (2023)

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential
por: Huang, Hai, et al.
Publicado: (2021)

PBK correlates with prognosis, immune escape and drug response in LUAD
por: Ma, Hongyu, et al.
Publicado: (2023)

Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto
por: Al-Malahmeh, Amer J., et al.
Publicado: (2016)

Development of a Generic Physiologically Based Kinetic Model to Predict In Vivo Uterotrophic Responses Induced by Estrogenic Chemicals in Rats Based on In Vitro Bioassays
por: Zhang, Mengying, et al.
Publicado: (2020)

Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine
por: van Dongen, Katja C. W., et al.
Publicado: (2022)

In Vitro Evaluation of the Individual and Combined Cytotoxic and Estrogenic Effects of Zearalenone, Its Reduced Metabolites, Alternariol, and Genistein
por: Balázs, Adrienn, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t01pi877avbdqcajcibtld71g5