A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer’s Disease in African Ancestry

African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other populations. Ancestry analysis showed that the difference in risk between African and European populations lies in the ancestral genomic background surrounding the ApoE locus (local ancestry). Identifying...

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Detalles Bibliográficos
Autores principales: Rajabli, Farid, Beecham, Gary W., Hendrie, Hugh C., Baiyewu, Olusegun, Ogunniyi, Adesola, Gao, Sujuan, Kushch, Nicholas A., Lipkin-Vasquez, Marina, Hamilton-Nelson, Kara L., Young, Juan I., Dykxhoorn, Derek M., Nuytemans, Karen, Kunkle, Brian W., Wang, Liyong, Jin, Fulai, Liu, Xiaoxiao, Feliciano-Astacio, Briseida E., Schellenberg, Gerard D., Dalgard, Clifton L., Griswold, Anthony J., Byrd, Goldie S., Reitz, Christiane, Cuccaro, Michael L., Haines, Jonathan L., Pericak-Vance, Margaret A., Vance, Jeffery M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286282/
https://www.ncbi.nlm.nih.gov/pubmed/35788729
http://dx.doi.org/10.1371/journal.pgen.1009977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286282/
https://www.ncbi.nlm.nih.gov/pubmed/35788729
http://dx.doi.org/10.1371/journal.pgen.1009977

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