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Active PD-L1 incorporation within HIV virions functionally impairs T follicular helper cells

The limited development of broadly neutralizing antibodies (BnAbs) during HIV infection is classically attributed to an inadequate B-cell help brought by functionally impaired T follicular helper (Tfh) cells. However, the determinants of Tfh-cell functional impairment and the signals contributing to...

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Detalles Bibliográficos
Autores principales: Munoz, Olivia, Banga, Riddhima, Schelling, Rachel, Procopio, Francesco Andrea, Mastrangelo, Andrea, Nortier, Pauline, Ohmiti, Khalid, Daraspe, Jean, Cavassini, Matthias, Fenwick, Craig, Perez, Laurent, Perreau, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286290/
https://www.ncbi.nlm.nih.gov/pubmed/35788752
http://dx.doi.org/10.1371/journal.ppat.1010673