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Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening
Mitochondria act as ‘sinks’ for Ca(2+) signaling, with mitochondrial Ca(2+) uptake linking physiological stimuli to increased ATP production. However, mitochondrial Ca(2+) overload can induce a cellular catastrophe by opening of the mitochondrial permeability transition pore (mPTP). This pore is a l...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286464/ https://www.ncbi.nlm.nih.gov/pubmed/31081999 http://dx.doi.org/10.1002/cpph.59 |