Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis

Oxidized phosphatidylcholines (OxPCs) are implicated in chronic tissue damage. Hyperlipidemic LDL-R-–deficient mice transgenic for an OxPC-recognizing IgM fragment (scFv-E06) are protected against nonalcoholic fatty liver disease (NAFLD). To examine the effect of OxPC elimination at different stages...

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Detalles Bibliográficos
Autores principales: Upchurch, Clint M., Yeudall, Scott, Pavelec, Caitlin M., Merk, Dennis, Greulich, Jan, Manjegowda, Mohan, Raghavan, Shyam S., Bochkis, Irina M., Scott, Michael M., Perez-Reyes, Edward, Leitinger, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286512/
https://www.ncbi.nlm.nih.gov/pubmed/35857497
http://dx.doi.org/10.1126/sciadv.abn0050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286512/
https://www.ncbi.nlm.nih.gov/pubmed/35857497
http://dx.doi.org/10.1126/sciadv.abn0050

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