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Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis

Oxidized phosphatidylcholines (OxPCs) are implicated in chronic tissue damage. Hyperlipidemic LDL-R-–deficient mice transgenic for an OxPC-recognizing IgM fragment (scFv-E06) are protected against nonalcoholic fatty liver disease (NAFLD). To examine the effect of OxPC elimination at different stages...

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Detalles Bibliográficos
Autores principales:	Upchurch, Clint M., Yeudall, Scott, Pavelec, Caitlin M., Merk, Dennis, Greulich, Jan, Manjegowda, Mohan, Raghavan, Shyam S., Bochkis, Irina M., Scott, Michael M., Perez-Reyes, Edward, Leitinger, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286512/ https://www.ncbi.nlm.nih.gov/pubmed/35857497 http://dx.doi.org/10.1126/sciadv.abn0050

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