Head‐to‐tail cyclization of side chain‐protected linear peptides to recapitulate genetically‐encoded cyclized peptides

Genetically‐encoded cyclic peptide libraries allow rapid in vivo screens for inhibitors of any target protein of interest. In particular, the Split Intein Circular Ligation of Protein and Peptides (SICLOPPS) system exploits spontaneous protein splicing of inteins to produce intracellular cyclic pept...

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Detalles Bibliográficos
Autores principales: Bouayad‐Gervais, Samir, St‐Cyr, Daniel J., Courcelles, Mathieu, Bonneil, Éric, Gohard, Florence H., Thibault, Pierre, Earnshaw, William C., Tyers, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286623/
https://www.ncbi.nlm.nih.gov/pubmed/35864841
http://dx.doi.org/10.1002/pep2.24254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286623/
https://www.ncbi.nlm.nih.gov/pubmed/35864841
http://dx.doi.org/10.1002/pep2.24254

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