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Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting

Pregnenolone methyl‐ether (PME) is a synthetic derivative of the endogenous neuroactive steroid pregnenolone (PREG), which is an important modulator of several brain functions. In addition to being the precursor of steroids, PREG acts directly on various targets including microtubules (MTs), the fun...

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Detalles Bibliográficos
Autores principales: Barbiero, Isabella, Bianchi, Massimiliano, Kilstrup‐Nielsen, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286658/
https://www.ncbi.nlm.nih.gov/pubmed/34495563
http://dx.doi.org/10.1111/jne.13033