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Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator
The Simcyp Simulator is a software platform for population physiologically‐based pharmacokinetic (PBPK) modeling and simulation. It links in vitro data to in vivo absorption, distribution, metabolism, excretion and pharmacokinetic/pharmacodynamic outcomes to explore clinical scenarios and support dr...
Autores principales: | Ezuruike, Udoamaka, Zhang, Mian, Pansari, Amita, De Sousa Mendes, Mailys, Pan, Xian, Neuhoff, Sibylle, Gardner, Iain |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286711/ https://www.ncbi.nlm.nih.gov/pubmed/35344639 http://dx.doi.org/10.1002/psp4.12791 |
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