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Evaluation of drug–drug interaction potential for pemigatinib using physiologically based pharmacokinetic modeling

Pemigatinib is a potent inhibitor of fibroblast growth factor receptor being developed for oncology indications. It is primarily metabolized by cytochrome P450 (CYP) 3A4, and the ratio of estimated concentration over concentration required for 50% inhibition ratio for pemigatinib as an inhibitor of...

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Detalles Bibliográficos
Autores principales: Ji, Tao, Chen, Xuejun, Yeleswaram, Swamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286713/
https://www.ncbi.nlm.nih.gov/pubmed/35506332
http://dx.doi.org/10.1002/psp4.12805