Robust physiologically based pharmacokinetic model of rifampicin for predicting drug–drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidney

P‐glycoprotein (P‐gp) is an efflux transporter that plays an important role in the pharmacokinetics of its substrate, and P‐gp activities can be altered by induction and inhibition effects of rifampicin. This study aimed to establish a physiologically based pharmacokinetic (PBPK) model of rifampicin...

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Detalles Bibliográficos
Autores principales: Asaumi, Ryuta, Nunoya, Ken‐ichi, Yamaura, Yoshiyuki, Taskar, Kunal S., Sugiyama, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286720/
https://www.ncbi.nlm.nih.gov/pubmed/35570332
http://dx.doi.org/10.1002/psp4.12807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286720/
https://www.ncbi.nlm.nih.gov/pubmed/35570332
http://dx.doi.org/10.1002/psp4.12807

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