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Simultaneous determination of eight analytes of Fuzheng Huayu recipe in beagle dog plasma by UHPLC–Q/exactive Orbitrap HRMS and its application to toxicokinetics

Fuzheng Huayu recipe (FZHY) is a Chinese patent medicine for the treatment of liver fibrosis. This study aimed to investigate the toxicokinetics of FZHY in beagle dogs after oral administration. Blood samples were collected on days 1, 15 and 28 after oral gavage of FZHY dosages of 400 or 1,200 mg/kg...

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Detalles Bibliográficos
Autores principales: Wang, Yu‐Lin, Yang, Ming‐jv, Li, Rong‐sheng, Hu, Ye‐qing, Pan, Yi‐feng, Yang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287080/
https://www.ncbi.nlm.nih.gov/pubmed/34997600
http://dx.doi.org/10.1002/bmc.5329