Structural insights into the function-modulating effects of nanobody binding to the integrin receptor α(M)β(2)

The integrin receptor α(M)β(2) mediates phagocytosis of complement-opsonized objects, adhesion to the extracellular matrix, and transendothelial migration of leukocytes. However, the mechanistic aspects of α(M)β(2) signaling upon ligand binding are unclear. Here, we present the first atomic structur...

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Detalles Bibliográficos
Autores principales: Jensen, Rasmus K., Pedersen, Henrik, Lorentzen, Josefine, Laursen, Nick Stub, Vorup-Jensen, Thomas, Andersen, Gregers Rom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287160/
https://www.ncbi.nlm.nih.gov/pubmed/35738398
http://dx.doi.org/10.1016/j.jbc.2022.102168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287160/
https://www.ncbi.nlm.nih.gov/pubmed/35738398
http://dx.doi.org/10.1016/j.jbc.2022.102168

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