Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate

Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6P). We present cryo-EM structures at 3.0–4.0 Å resolution of...

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Detalles Bibliográficos
Autores principales: McCorvie, Thomas J., Loria, Paula M., Tu, Meihua, Han, Seungil, Shrestha, Leela, Froese, D. Sean, Ferreira, Igor M., Berg, Allison P., Yue, Wyatt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287172/
https://www.ncbi.nlm.nih.gov/pubmed/35835870
http://dx.doi.org/10.1038/s41594-022-00799-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287172/
https://www.ncbi.nlm.nih.gov/pubmed/35835870
http://dx.doi.org/10.1038/s41594-022-00799-3

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