Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently

BACKGROUND: Activities of hepatic cytochrome P450 enzymes (CYPs) are relevant for hepatic clearance of drugs and known to be decreased in patients with liver cirrhosis. Several studies have reported the effect of liver cirrhosis on CYP activity, but the results are partially conflicting and for some...

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Detalles Bibliográficos
Autores principales: Duthaler, Urs, Bachmann, Fabio, Suenderhauf, Claudia, Grandinetti, Tanja, Pfefferkorn, Florian, Haschke, Manuel, Hruz, Petr, Bouitbir, Jamal, Krähenbühl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287224/
https://www.ncbi.nlm.nih.gov/pubmed/35570253
http://dx.doi.org/10.1007/s40262-022-01119-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287224/
https://www.ncbi.nlm.nih.gov/pubmed/35570253
http://dx.doi.org/10.1007/s40262-022-01119-0

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