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Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently
BACKGROUND: Activities of hepatic cytochrome P450 enzymes (CYPs) are relevant for hepatic clearance of drugs and known to be decreased in patients with liver cirrhosis. Several studies have reported the effect of liver cirrhosis on CYP activity, but the results are partially conflicting and for some...
Autores principales: | Duthaler, Urs, Bachmann, Fabio, Suenderhauf, Claudia, Grandinetti, Tanja, Pfefferkorn, Florian, Haschke, Manuel, Hruz, Petr, Bouitbir, Jamal, Krähenbühl, Stephan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287224/ https://www.ncbi.nlm.nih.gov/pubmed/35570253 http://dx.doi.org/10.1007/s40262-022-01119-0 |
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