Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition

Aggresome formation is a protective cellular response to counteract proteasome dysfunction by sequestering misfolded proteins and reducing proteotoxic stress. Autophagic degradation of the protein aggregates is considered to be a key compensating mechanism for balancing proteostasis. However, the pr...

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Detalles Bibliográficos
Autores principales: Zhang, Chenliang, Huang, Chen, Xia, Hongwei, Xu, Huanji, Tang, Qiulin, Bi, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287315/
https://www.ncbi.nlm.nih.gov/pubmed/35840557
http://dx.doi.org/10.1038/s41419-022-05061-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287315/
https://www.ncbi.nlm.nih.gov/pubmed/35840557
http://dx.doi.org/10.1038/s41419-022-05061-8

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