Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling

Increasing or restoring Bone Morphogenetic Protein receptor signaling is an effective therapy for conditions such as bone fracture and pulmonary arterial hypertension. However, direct use of recombinant BMPs has encountered significant obstacles. Moreover, synthetic, full agonists of BMP receptor si...

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Detalles Bibliográficos
Autores principales: Najafi, Sheyda, Barasa, Leonard, Huang, Sammy Y., Yoganathan, Sabesan, Perron, Jeanette C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287337/
https://www.ncbi.nlm.nih.gov/pubmed/35840622
http://dx.doi.org/10.1038/s41598-022-16394-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287337/
https://www.ncbi.nlm.nih.gov/pubmed/35840622
http://dx.doi.org/10.1038/s41598-022-16394-x

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