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Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides
Substitutions, insertions, and deletions derived from synthetic oligonucleotides are the hurdles for the synthesis of long DNA such as genomes. We quantified these synthetic errors by next-generation sequencing and revealed that the quality of the enzymatically amplified final combined product depen...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287346/ https://www.ncbi.nlm.nih.gov/pubmed/35840646 http://dx.doi.org/10.1038/s41598-022-16222-2 |