Trigger factor both holds and folds its client proteins

ATP-independent chaperones like trigger factor are generally assumed to play passive roles in protein folding by acting as holding chaperones. Here we show that trigger factor plays a more active role. Consistent with a role as an aggregation inhibiting chaperone, we find that trigger factor rapidly...

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Detalles Bibliográficos
Autores principales: Wu, Kevin, Minshull, Thomas C., Radford, Sheena E., Calabrese, Antonio N., Bardwell, James C. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287376/
https://www.ncbi.nlm.nih.gov/pubmed/35840586
http://dx.doi.org/10.1038/s41467-022-31767-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287376/
https://www.ncbi.nlm.nih.gov/pubmed/35840586
http://dx.doi.org/10.1038/s41467-022-31767-6

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