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Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM
MrgD, a member of the Mas-related G protein-coupled receptor (MRGPR) family, has high basal activity for Gi activation. It recognizes endogenous ligands, such as β-alanine, and is involved in pain and itch signaling. The lack of a high-resolution structure for MrgD hinders our understanding of wheth...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287403/ https://www.ncbi.nlm.nih.gov/pubmed/35840655 http://dx.doi.org/10.1038/s42003-022-03668-3 |