Transcription-associated DNA DSBs activate p53 during hiPSC-based neurogenesis

Neurons are overproduced during cerebral cortical development. Neural progenitor cells (NPCs) divide rapidly and incur frequent DNA double-strand breaks (DSBs) throughout cortical neurogenesis. Although half of the neurons born during neurodevelopment die, many neurons with inaccurate DNA repair sur...

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Detalles Bibliográficos
Autores principales: Michel, Nadine, Young, Heather M. Raimer, Atkin, Naomi D., Arshad, Umar, Al-Humadi, Reem, Singh, Sandeep, Manukyan, Arkadi, Gore, Lana, Burbulis, Ian E., Wang, Yuh-Hwa, McConnell, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287420/
https://www.ncbi.nlm.nih.gov/pubmed/35840793
http://dx.doi.org/10.1038/s41598-022-16516-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287420/
https://www.ncbi.nlm.nih.gov/pubmed/35840793
http://dx.doi.org/10.1038/s41598-022-16516-5

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