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Inhibition of NMDA receptors through a membrane-to-channel path

N-methyl-d-aspartate receptors (NMDARs) are transmembrane proteins that are activated by the neurotransmitter glutamate and are found at most excitatory vertebrate synapses. NMDAR channel blockers, an antagonist class of broad pharmacological and clinical significance, inhibit by occluding the NMDAR...

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Detalles Bibliográficos
Autores principales: Wilcox, Madeleine R., Nigam, Aparna, Glasgow, Nathan G., Narangoda, Chamali, Phillips, Matthew B., Patel, Dhilon S., Mesbahi-Vasey, Samaneh, Turcu, Andreea L., Vázquez, Santiago, Kurnikova, Maria G., Johnson, Jon W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287434/
https://www.ncbi.nlm.nih.gov/pubmed/35840593
http://dx.doi.org/10.1038/s41467-022-31817-z